Multifunctional POSS-based nanoparticles functionalized with silver, SPIONs, and rhamnolipid for antibacterial applications

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dc.contributor.authorKibar, Gunes
dc.contributor.authorKafali, Melisa
dc.contributor.authorOzonuk, Olgu Cagan
dc.contributor.authorOztas, Merve
dc.contributor.authorUsta, Berk
dc.contributor.authorErcan, Batur
dc.date.accessioned2026-02-27T07:33:41Z
dc.date.available2026-02-27T07:33:41Z
dc.date.issued2026
dc.description.abstractNano-engineered materials, particularly those featuring bio-based surface modifications, are emerging as effective tools in combating bacterial infections. In this study, polyhedral oligomeric silsesquioxane (POSS) nanoparticles were functionalized with silver nanoparticles (Ag), superparamagnetic iron oxide nanoparticles (SPIONs), and the biosurfactant rhamnolipid (RL)-either individually or in combination-to evaluate their antibacterial and antibiofilm activities against Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa). The modified nanoparticles exhibited sizes ranging from 127 to 227 nm and demonstrated superparamagnetic behavior, offering potential for magnetic targeting. Among the various formulations, the RLcoated, silver- and SPION-decorated POSS nanoparticles (RSMP) exhibited the highest antibacterial efficacy, reducing S. aureus and P. aeruginosa colony growth by approximately 90 % and 66 %, respectively, at a concentration of 0.01 g/L. RSMP nanoparticles also showed strong biofilm inhibition and had the lowest MIC50 values. Notably, these nanoparticles supported the proliferation of human osteoblasts at concentrations up to 0.05 g/L, indicating favorable cytocompatibility. Overall, RSMP nanoparticles present a promising platform for magnetically targetable antibacterial agents, with potential applications in biomedical fields, particularly for managing orthopedic infections.
dc.description.sponsorshipAdana Alparslan Tirkes Science and Technology University [22103005]; Scientific and Technological Research Council of Turkey [122C223]; Fulbright Post-doctoral Scholarship [TBI bull; TAK 2219, 1059B191801017]; TUBITAK [123M943]; Shriners Hospitals for Children Research Grant [SHC 85700]
dc.description.sponsorshipThis work was supported by Adana Alparslan Tirkes Science and Technology University (Grant No. 22103005) and The Scientific and Technological Research Council of Turkey (TUEBI center dot TAK, Grant No. 122C223) . Gines Kibar acknowledges support from the Fulbright Post-doctoral Scholarship and TUEBI center dot TAK 2219 International Postdoctoral Research Fellowship Program (Grant No. 1059B191801017) . Merve Oztas acknowledges the scholarship support provided by TUBITAK (Grant No. 123M943) . Additionally, this work was partially supported by the Shriners Hospitals for Children Research Grant (Grant No. SHC 85700) .
dc.identifier.doi10.1016/j.bioadv.2025.214678
dc.identifier.issn2772-9508
dc.identifier.pmid41483732
dc.identifier.urihttp://dx.doi.org/10.1016/j.bioadv.2025.214678
dc.identifier.urihttps://hdl.handle.net/20.500.14669/4673
dc.identifier.volume182
dc.identifier.wosWOS:001659342700001
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofBiomaterials Advances
dc.relation.publicationcategoryMakale - Uluslararas� Hakemli Dergi - Kurum ��retim Eleman�
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20260302
dc.subjectPolyhedral oligomeric silsesquioxane (POSS)
dc.subjectSuperparamagnetic iron oxide (SPION)
dc.subjectSilver nanoparticles
dc.subjectPolydopamine
dc.subjectRhamnolipid
dc.subjectAntibacterial
dc.subjectAntibiofilm
dc.subjectOsteoblast
dc.titleMultifunctional POSS-based nanoparticles functionalized with silver, SPIONs, and rhamnolipid for antibacterial applications
dc.typeArticle

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