Effects of Juniperus drupacea concurrent with etoposide on glioblastoma cell culture

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dc.authoridOzdemir Alkis, Meryem Damla/0000-0002-5728-8004
dc.authoridGokturk, Dilek/0000-0002-1195-5828
dc.contributor.authorGokturk, Dilek
dc.contributor.authorAlkis, Meryem Damla Ozdemir
dc.date.accessioned2025-01-06T17:43:24Z
dc.date.available2025-01-06T17:43:24Z
dc.date.issued2023
dc.description.abstractGlioblastoma (GBM) is a prevalent and most malignant kind of glioma, reported as grade IV glioma by the World Health Organization. In a year 3-10 per 100.000 people are diagnosed with GBM and their mean life expectancy could only be 12-16 months after diagnosis.Juniperus drupacea, a member of the Cupressaceae family is a medicinal herb. In this study, the free radical scavenging activity and volatile components of Juniperus drupacea were analyzed and the cytotoxic effects of Juniperus drupacea molasses and cone seed extract in combination with etoposide on GBM cell line (U-87 MG (ATCC (R) HTB-14TM)) were evaluated. Furthermore, the impact of Juniperus drupacea extract on the migration capacity of GBM cells was examined. Based on the DPPH radical scavenging activity assay, the amount of free radical-binding antioxidants in the Juniperus drupacea extract was found to be 0.575 mg/mL Trolox equivalent. The results of the cytotoxicity and migration assays revealed that Juniperus drupacea reduced the viability and migration capacity of GBM cells and increase the cytotoxic effect of etoposide. Considering these findings, it was hypothesized that some of the components of Juniperus drupacea might have possible therapeutic effects for the treatment of glioblastoma.(c) 2023 SAAB. Published by Elsevier B.V. All rights reserved.
dc.identifier.doi10.1016/j.sajb.2023.10.033
dc.identifier.endpage180
dc.identifier.issn0254-6299
dc.identifier.issn1727-9321
dc.identifier.scopus2-s2.0-85174838702
dc.identifier.scopusqualityQ1
dc.identifier.startpage172
dc.identifier.urihttps://doi.org/10.1016/j.sajb.2023.10.033
dc.identifier.urihttps://hdl.handle.net/20.500.14669/2654
dc.identifier.volume163
dc.identifier.wosWOS:001102841000001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofSouth African Journal of Botany
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241211
dc.subjectJuniperus drupacea
dc.subjectMedicinal herb
dc.subjectGlioblastoma
dc.subjectEtoposide
dc.titleEffects of Juniperus drupacea concurrent with etoposide on glioblastoma cell culture
dc.typeArticle

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