Effect of polymer concentration in cryogelation of gelatin and poly (vinyl alcohol) scaffolds

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dc.authoriddemir, didem/0000-0002-2977-2077
dc.authoridceylan, seda/0000-0002-1088-7886
dc.contributor.authorCeylan, Seda
dc.contributor.authorDemir, Didem
dc.contributor.authorGul, Gulsah
dc.contributor.authorBolgen, Nimet
dc.date.accessioned2025-01-06T17:38:07Z
dc.date.available2025-01-06T17:38:07Z
dc.date.issued2019
dc.description.abstractThe aim of this study was to investigate the effect of total polymer concentration on the chemical structure, morphology of pores, porosity, swelling ratio, degradation of gelatin-poly (vinyl alcohol) (Gel-PVA) cryogel scaffolds. Porous cryogels were prepared with cryogelation technique by using glutaraldehyde as a crosslinker. Functional group composition of cryogels after crosslinking was investigated by Fourier Transform Infrared (FTIR). The morphology of cryogels was characterized via scanning electron microscopy (SEM) and porosity analysis. All of the cryogels had a porous structure with an average pore size between 45.58 +/- 14.28 and 50.14 +/- 4.26 mu m. The cryogels were biodegradable and started to degrade in 14 days. As the polymer concentration increased the swelling ratio, the porosity and the degradation rate decreased. Spongy and mechanically stable Gel-PVA cryogels, with tunable properties, can be potential candidates as scaffolds for tissue engineering applications.
dc.description.sponsorshipScientific Research Projects Unit of Mersin University [BAP-2018-1-TP3-2731]
dc.description.sponsorshipThis work was supported by The Scientific Research Projects Unit of Mersin University BAP-2018-1-TP3-2731.
dc.identifier.doi10.12989/bme.2019.4.1.001
dc.identifier.endpage8
dc.identifier.issn2465-9835
dc.identifier.issn2465-9959
dc.identifier.issue1
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.12989/bme.2019.4.1.001
dc.identifier.urihttps://hdl.handle.net/20.500.14669/2483
dc.identifier.volume4
dc.identifier.wosWOS:000463314100001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherTechno-Press
dc.relation.ispartofBiomaterials and Biomechanics in Bioengineering
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241211
dc.subjectgelatin
dc.subjectpoly (vinyl alcohol)
dc.subjectcryogel
dc.subjectscaffold
dc.subjecttissue engineering
dc.titleEffect of polymer concentration in cryogelation of gelatin and poly (vinyl alcohol) scaffolds
dc.typeArticle

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