Morphometric effectiveness of calcium hydroxylapatite application in zygomatic and malar area on correction of nasolabial folds

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dc.authoridTandirovic Gursel, Amira/0000-0002-9219-3203
dc.authoridAyd�n, Bar��/0000-0003-0604-8243
dc.contributor.authorKabakci, Ayse Gul
dc.contributor.authorGursel, Amira Tandirovic
dc.contributor.authorAydin, Baris
dc.contributor.authorEren, Dilek
dc.contributor.authorBozkir, Memduha Gulhal
dc.date.accessioned2026-02-27T07:33:11Z
dc.date.available2026-02-27T07:33:11Z
dc.date.issued2025
dc.description.abstractThis study aims to investigate the indirect effects of calcium hydroxylapatite (CaHA) injections in the zygomatic and malar regions on the healing of nasolabial folds (NLFs). Given the anatomical complexity and proximity of the nasolabial area, selecting appropriate techniques for CaHA applications is crucial to prevent potential complications. The study is designed to contribute insights into the safety and efficacy of injections, aiming to enhance patient outcomes and minimize risks in aesthetic applications. This retrospective single-center study analyzed the effectiveness of CaHA injections in the zygomatic and malar regions for correcting NLFs in 51 female participants aged between 30 and 55. Images from clinical archives were used, taken before the application and 6 months after the application. The primary outcomes were evaluated using Gabor filter analysis, Global Aesthetic Improvement Scale, and Wrinkle Severity Rating Scale, complemented by morphometric measurements using Image J 1.52a software. Measurements before and 6 months after the application revealed significant improvements in NLF length: from 2.59 +/- 0.64 cm to 2.24 +/- 0.53 cm on the right side and from 2.76 +/- 0.81 cm to 2.59 +/- 0.61 cm on the left side. This corresponds to an improvement of 13.51 % and 6.16%, respectively. Evaluations using the Wrinkle Severity Rating Scale, Global Aesthetic Improvement Scale scores, and Gabor filter analysis also demonstrated positive NLF depth post-treatment changes. The results of our study indicate that CaHA injections in the zygomatic and malar regions lead to an indirect improvement in NLFs. Furthermore, our study provides standardized quantitative methods that can be used to assess the effectiveness of treatments in the nasolabial area. These analyses offer reliable tools for evaluating aesthetic procedures and provide valuable contributions to clinical practice.
dc.description.sponsorshipBurgeon Biotechnology
dc.description.sponsorshipThis study was funded by Burgeon Biotechnology. Funder website: https://burgeon.me/. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript
dc.identifier.doi10.1097/MD.0000000000043477
dc.identifier.issn0025-7974
dc.identifier.issn1536-5964
dc.identifier.issue29
dc.identifier.pmid40696634
dc.identifier.urihttp://dx.doi.org/10.1097/MD.0000000000043477
dc.identifier.urihttps://hdl.handle.net/20.500.14669/4477
dc.identifier.volume104
dc.identifier.wosWOS:001533500100027
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofMedicine
dc.relation.publicationcategoryMakale - Uluslararas� Hakemli Dergi - Kurum ��retim Eleman�
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20260302
dc.subjectcalcium hydroxylapatite
dc.subjectmalar area
dc.subjectmorphometry
dc.subjectnasolabial fold
dc.subjectzygomatic area
dc.titleMorphometric effectiveness of calcium hydroxylapatite application in zygomatic and malar area on correction of nasolabial folds
dc.typeArticle

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