Chitosan based injectable cryospheres as a potential biopolymeric carrier for drug delivery systems: Characterization, biocompatibility and drug release

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dc.authoridBolgen, Nimet/0000-0003-3162-0803
dc.contributor.authorDemir, Didem
dc.contributor.authorCeylan, Seda
dc.contributor.authorBolgen, Nimet
dc.date.accessioned2025-01-06T17:36:58Z
dc.date.available2025-01-06T17:36:58Z
dc.date.issued2024
dc.description.abstractThree-dimensional scaffolds with the right design to support cell metabolism and the right physico-chemical, mechanical, and biological qualities have become more interesting for tissue engineering because of the complexity and diversity of the tissues involved. Moreover, three-dimensional scaffolds with tuneable drug delivery capabilities have drawn more attention in the field of soft tissue engineering. In this research, chitosanbased microspheres (called cryospheres) were fabricated in spherical shapes micron-sized with highly interconnected porous structures as a result of combining emulsification and cryogelation methods. The characterization of cryospheres was evaluated using morphological, physicochemical, and biological analyses. According to the results of the in vitro and in vivo biocompatibility investigation, the microspheres had no toxic effects on cell survival, and they even enhanced cell viability at the implantation site when compared to the control group. After the cryospheres were characterized, research was done on drug loading, drug release, and release processes using two distinct dyes (Nile Red: NR and Rhodamine-B: RB) in simulated body fluids (simulated intestinal, stomach, and tear fluids). The results showed that the maximum drug loading capacities for RB and NR were 89.32 +/- 1.57 % and 61.51 +/- 0.70 %, respectively. This study contributed to the development of minimally invasive biomaterials that have the potential to provide both drug release and tissue formation/regeneration at damaged implantation sites by carrying not only drugs but also active substances such as hormones/growth factors that will trigger new tissue formation.
dc.description.sponsorshipMersin University Scientific Research Projects Unit [2018-1-TP3-2912]
dc.description.sponsorshipThis study was carried out within the scope of the PhD program of the Chemical Engineering Department, Mersin University, Turkiye. It was financially supported by the Mersin University Scientific Research Projects Unit (2018-1-TP3-2912) . The authors would like to thank TUBITAK MAM for the implantation test.
dc.identifier.doi10.1016/j.jddst.2024.106406
dc.identifier.issn1773-2247
dc.identifier.issn2588-8943
dc.identifier.scopus2-s2.0-85209369186
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.jddst.2024.106406
dc.identifier.urihttps://hdl.handle.net/20.500.14669/2056
dc.identifier.volume102
dc.identifier.wosWOS:001361269300001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Drug Delivery Science and Technology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241211
dc.subjectChitosan
dc.subjectMicrosphere
dc.subjectInjectable
dc.subjectDrug delivery systems
dc.subjectRelease kinetic
dc.titleChitosan based injectable cryospheres as a potential biopolymeric carrier for drug delivery systems: Characterization, biocompatibility and drug release
dc.typeArticle

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