Genome-Wide Integrative Analysis Reveals Common Molecular Signatures in Blood and Brain of Alzheimer's Disease

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dc.authoridHolsinger, R. M. Damian/0000-0002-4447-0835
dc.authoridMoni, Mohammad Ali/0000-0003-0756-1006
dc.contributor.authorRahman, Md Rezanur
dc.contributor.authorIslam, Tania
dc.contributor.authorShabjam, Md
dc.contributor.authorRana, Md Humayun Kabir
dc.contributor.authorHolsinger, R. M. Damian
dc.contributor.authorQuinn, Julian M. W.
dc.contributor.authorGov, Esra
dc.date.accessioned2025-01-06T17:36:15Z
dc.date.available2025-01-06T17:36:15Z
dc.date.issued2021
dc.description.abstractThe currently utilized neuroimaging and cerebrospinal fluid-based detection of Alzheimers disease (AD) suffer several limitations, including sensitivity, specificity, and cost. Therefore, the identification of AD by analyzing blood gene expression may ameliorate the early diagnosis of the AD. We aimed to identify common genes commonly deregulated in blood and brain in AD. Comprehensive analysis of blood and brain gene expression datasets of AD, eQTL, and epigenetics data was analyzed by the integrative bioinformatics approach. The integrative analysis showed nine differentially expressed genes common to blood cells and brain (CNBD1, SUCLG2-AS1, CCDC65, PDE4D, MTMR1, C3, SLC6A15, LINC01806, and FRG1JP). Analysis of SNP and cis-eQTL data showed 18 genes; namely, HSD17B1, GAS5, RPS5, VKORC1, GLE1, WDR1, RPL12, MORN1, RAD52, SDR39U1, NPHP4, MT1E, SORD, LINC00638, MCM3AP-AS1, GSDMD, RPS9, and GNL2 were observed deregulated AD blood and brain tissues. Functional gene set enrichment analysis demonstrated a significant association of these genes in neurodegeneration-associated molecular pathways. Integrative biomolecular networks revealed dysregulation of several hub transcription factors and microRNAs in AD. Moreover, hub genes were observed associated with significant histone modification. This study detected common molecular biomarkers and pathways in blood and brain tissues in AD that may be potential biomarkers and therapeutic targets in AD.
dc.identifier.doi10.33263/BRIAC112.86868701
dc.identifier.endpage8701
dc.identifier.issn2069-5837
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85090980215
dc.identifier.scopusqualityQ2
dc.identifier.startpage8686
dc.identifier.urihttps://doi.org/10.33263/BRIAC112.86868701
dc.identifier.urihttps://hdl.handle.net/20.500.14669/1817
dc.identifier.volume11
dc.identifier.wosWOS:000570975300008
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherBiointerface Research Applied Chemistry
dc.relation.ispartofBiointerface Research in Applied Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241211
dc.subjectAlzheimer's disease
dc.subjectmolecular signature
dc.subjectblood-brain common gene
dc.subjectdifferentially expressed genes
dc.subjectprotein-protein interactions
dc.subjectepigenetics
dc.titleGenome-Wide Integrative Analysis Reveals Common Molecular Signatures in Blood and Brain of Alzheimer's Disease
dc.typeArticle

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