Combinations of Interleukin-10 Gene Promoter Polymorphisms with -1082A, -819T, -592A Minor Allele are Associated with Sinonasal Polyposis.

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dc.contributor.authorOzdas, Sibel
dc.date.accessioned2025-01-06T17:22:38Z
dc.date.available2025-01-06T17:22:38Z
dc.date.issued2018
dc.departmentAdana Alparslan Türkeş Bilim ve Teknoloji Üniversitesi
dc.description.abstractSinonasal polyposis (SP) is an inflammatory disease involving multiple etiologies andpathogenesis. The disarray of Interleukin (IL)-10 is associated with a raised immunopathologicalresponse during the progression of many autoimmune diseases as well as theresponse to infection. We studied the possible role of the single nucleotide polymorphisms(SNPs) in IL-10 gene and their genotypic combinations in the SP pathogenesis. The IL-10’spromoter was genotyped in 200 participants (100 patients and 100 controls). The sites thatwere encompassed -1082, -819, and -592 SNP regions of extracted DNAs were analyzedby sequencing for polymorphisms. The IL-10 gene promoter polymorphisms with -1082A,-819T, -592A minor alleles, their heterozygotes and homozygotes mutant genotypes hadsignificantly higher risks for SP (P<0.05). Also, haplotype analysis demonstrated that theGTC, ACC, and GCA haplotypes in IL-10 were high-risk of SP but ATA was only incontrols (P= 0.007). Also, the multifactor dimensionality reduction (MDR) analysis indicatedthat the IL-10-1082_-819 and -1082_-819_-592 were the best predictive modelsfor SP with 66.6% and 69% accuracy, respectively. IL-10 genotypic variations and theircombinations are linked with a high-risk for the SP development in the Turkish population.The IL-10 genetic polymorphisms may lend to SP by altering the arrangement of the geneexpression, affecting the severity of the inflammatory response.
dc.identifier.doi10.17350/HJSE19030000105
dc.identifier.endpage292
dc.identifier.issn2149-2123
dc.identifier.issn2148-4171
dc.identifier.issue4
dc.identifier.startpage285
dc.identifier.trdizinid382701
dc.identifier.urihttps://doi.org/10.17350/HJSE19030000105
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/382701
dc.identifier.urihttps://hdl.handle.net/20.500.14669/432
dc.identifier.volume5
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofHittite Journal of Science and Engineering
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241211
dc.subjectGenetik ve Kalıtım
dc.subjectBiyokimya ve Moleküler Biyoloji
dc.subjectİmmünoloji
dc.titleCombinations of Interleukin-10 Gene Promoter Polymorphisms with -1082A, -819T, -592A Minor Allele are Associated with Sinonasal Polyposis.
dc.typeArticle

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