Combinations of Interleukin-10 Gene Promoter Polymorphisms with -1082A, -819T, -592A Minor Allele are Associated with Sinonasal Polyposis.

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Tarih

2018

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

Sinonasal polyposis (SP) is an inflammatory disease involving multiple etiologies andpathogenesis. The disarray of Interleukin (IL)-10 is associated with a raised immunopathologicalresponse during the progression of many autoimmune diseases as well as theresponse to infection. We studied the possible role of the single nucleotide polymorphisms(SNPs) in IL-10 gene and their genotypic combinations in the SP pathogenesis. The IL-10’spromoter was genotyped in 200 participants (100 patients and 100 controls). The sites thatwere encompassed -1082, -819, and -592 SNP regions of extracted DNAs were analyzedby sequencing for polymorphisms. The IL-10 gene promoter polymorphisms with -1082A,-819T, -592A minor alleles, their heterozygotes and homozygotes mutant genotypes hadsignificantly higher risks for SP (P<0.05). Also, haplotype analysis demonstrated that theGTC, ACC, and GCA haplotypes in IL-10 were high-risk of SP but ATA was only incontrols (P= 0.007). Also, the multifactor dimensionality reduction (MDR) analysis indicatedthat the IL-10-1082_-819 and -1082_-819_-592 were the best predictive modelsfor SP with 66.6% and 69% accuracy, respectively. IL-10 genotypic variations and theircombinations are linked with a high-risk for the SP development in the Turkish population.The IL-10 genetic polymorphisms may lend to SP by altering the arrangement of the geneexpression, affecting the severity of the inflammatory response.

Açıklama

Anahtar Kelimeler

Genetik ve Kalıtım, Biyokimya ve Moleküler Biyoloji, İmmünoloji

Kaynak

Hittite Journal of Science and Engineering

WoS Q Değeri

Scopus Q Değeri

Cilt

5

Sayı

4

Künye