Preparation and characterization of hydroxyapatite reinforced polymeric scaffolds

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dc.contributor.authorFirata, Duygu Doga
dc.contributor.authorErsoz, Su Turku
dc.contributor.authorBurcu Alp, Fatma
dc.contributor.authorCetin, Ali Emrah
dc.contributor.authorCiftcioglu, Muhsin
dc.date.accessioned2026-02-27T07:33:32Z
dc.date.available2026-02-27T07:33:32Z
dc.date.issued2025
dc.description.abstractPorous HA reinforced PLA/PCL scaffolds with polymer volume percentages in the 7.0-7.6 range have been prepared by solvent-casting/salt leaching technique. The scaffolds have been characterized by conducting gravimetric measurements, FTIR analysis, TGA, X-ray diffraction analysis, compression tests, cell viability tests, and thermal and hydrolytic degradation tests in order to investigate the effect of PLA/PCL, PLA/HA, PCL/HA and PLA/PCL/HA blending on scaffold properties. Porosity of the scaffolds has been determined to be in the 83-92 percent range. The scaffold porosity has decreased with HA content. The water absorption of the scaffolds has been found to be in between 400 and 750%. The yield strength and the elastic modulus of the scaffolds have been determined to be in the 0.001-0.02 and 5.6-10.6 MPa ranges, respectively. The yield strength of the scaffolds has increased by both PCL and HA contents whereas elastic modulus has increased with PCL content but has decreased with HA content. Mechanical test results have indicated that the addition of HA has increased the strength of the scaffolds while decreasing their flexibility. The activation energies for the thermal degradation of the scaffolds have been determined to be in the 130-398 kJ/mol range and have been shown to be a function of PCL, PLA, and HA content. The hydrolytic degradation behavior of the scaffolds in acetate buffer solutions (pH=4.5) during 127 days and XRD analysis have indicated that the hydrolytic degradation occurring in the amorphous part of the surface film has been diffusion-controlled. The diffusion coefficients of the degradation products in the scaffolds have been estimated to be in the 1.21-4.95x10(-13) m(2)/s range. Cell viability test results have indicated that the composition of the composite scaffold structure has played a determining role in the prepared scaffolds.
dc.identifier.doi10.56042/ijems.v32i03.15630
dc.identifier.endpage409
dc.identifier.issn0971-4588
dc.identifier.issn0975-1017
dc.identifier.issue3
dc.identifier.startpage394
dc.identifier.urihttp://dx.doi.org/10.56042/ijems.v32i03.15630
dc.identifier.urihttps://hdl.handle.net/20.500.14669/4628
dc.identifier.volume32
dc.identifier.wosWOS:001615154200009
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherNational Institute of Science Communication and Information Resources-NISCAIR
dc.relation.ispartofIndian Journal of Engineering and Materials Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20260302
dc.subjectHydrolytic degradation
dc.subjectHydroxyapatite
dc.subjectPoly(epsilon-caprolactone)
dc.subjectPoly(L-lactic acid)
dc.subjectScaffold
dc.subjectThermal degradation
dc.titlePreparation and characterization of hydroxyapatite reinforced polymeric scaffolds
dc.typeArticle

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