Determining the significance weights of ALSFRS-R items using analytic hierarchy process

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dc.contributor.authorKoc, Gizem
dc.contributor.authorEranay, Fatih
dc.contributor.authorKokangul, Ali
dc.contributor.authorKoc, Filiz
dc.date.accessioned2025-01-06T17:30:26Z
dc.date.available2025-01-06T17:30:26Z
dc.date.issued2023
dc.description.abstractObjective: The objective of the study was to determine the significance weights of the Revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R) item scores for better evaluation and classification of amyotrophic lateral sclerosis (ALS) status. Methods: We used an analytical hierarchy process (AHP) to determine the weights of the ALSFRS-R item scores based on the opinions of two neurologists. We analyzed data of 51 patients with ALS to group them into four ALS severity classes based on their (i) total ALSFRS-R score and (ii) total weighted ALSFRS-R scores using the proposed weight values. We analyzed the performance differences between the two classification approaches based on the outcomes of these 51 patients. We also used twenty additional patients' data to analyze the accuracies of the total and weighted ALSFRS-R score approaches compared with physicians' actual assessments. Results: The AHP analysis assigned the highest weights to the ALSFRS-R items for respiratory insufficiency, orthopnea, and bed rotation/covering. ALS status classification based on the total and weighted ALSFRS-R scores differed for about 27.5% (confidence interval [CI]: 15.2%-39.8%) of the 51 patients. The classification based on the total weighted ALSFRS-R complied with the actual assessments in 85% (CI: 69.4%-100%) of the patients in the comparison sample; the compliance rate was 60% (CI: 38.5%-81.5%) for the total ALSFRS-R-based classification. Conclusions: Assigning weights to the 12 ALSFRS-R criteria/questions may improve ALSFRS-R's ability to represent ALS severity. This finding requires further investigation. © 2023 AVES. All rights reserved.
dc.identifier.doi10.4103/nsn.nsn_4_23
dc.identifier.endpage94
dc.identifier.issn2636-865X
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85165965855
dc.identifier.scopusqualityQ4
dc.identifier.startpage88
dc.identifier.trdizinid1263546
dc.identifier.urihttps://doi.org/10.4103/nsn.nsn_4_23
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1263546
dc.identifier.urihttps://hdl.handle.net/20.500.14669/1621
dc.identifier.volume40
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofNeurological Sciences and Neurophysiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241211
dc.subjectAmyotrophic lateral sclerosis
dc.subjectanalytical hierarchy procedure
dc.subjectdisease classification
dc.subjectRevised Amyotrophic Lateral Sclerosis Functional Rating Scale
dc.subjectscoring
dc.titleDetermining the significance weights of ALSFRS-R items using analytic hierarchy process
dc.typeArticle

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