Unpacking early risks for peer victimization: A network analysis of early temperament and polygenic risk scores

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dc.authoridWu, Tom/0000-0002-3468-0943
dc.contributor.authorWu, Tom C. H.
dc.contributor.authorKonac, Deniz
dc.contributor.authorGarcia-mondragon, Liliana
dc.contributor.authorMartin, Alex F.
dc.contributor.authorMaughan, Barbara
dc.contributor.authorBarker, Ted
dc.date.accessioned2026-02-27T07:33:40Z
dc.date.available2026-02-27T07:33:40Z
dc.date.issued2026
dc.description.abstractBackground Children who show difficult temperament are at risk of peer victimisation, which in turn associates with numerous negative outcomes later in life. We used network analysis to examine whether specific aspects of difficult temperament contributed to these associations, and whether the links were moderated by variations in genetic liability for ADHD, schizophrenia, and depression.Methods In 3354 mother-child dyads (51.8% female), we examined in three steps: (i) the network structure of difficult temperament as indexed by adaptability, intensity, and mood (age 2), (ii) its item-level associations with peer victimisation (ages 8, 10, and 13), and (iii) moderation of these associations by polygenic risk scores (PRS) for ADHD, schizophrenia, and depression.Results Indicators of difficult temperament formed a coherent network that was associated with peer victimisation. Regarding PRS moderation, for those high in PRS (top 10%) for ADHD and schizophrenia, indicators of temperamental intensity and mood were associated with peer victimisation, respectively. For those high in PRS for depression, however, aspects of temperament were no longer associated with peer victimisation. Finally, the network results for those in the general population across all PRS (bottom 90%) largely resembled the model estimated using the full sample.Conclusion The findings highlight specific temperamental behaviours as risk factors for peer victimisation; additionally, children high in PRS for neurodevelopmental disorders may be at especially high-risk for this outcome early in development.
dc.description.sponsorshipEunice Kennedy Shriver National Institute of Child Health and Human Development [R01HD068437]
dc.description.sponsorshipEunice Kennedy Shriver National Institute of Child Health and Human Development, Grant/Award Number: R01HD068437
dc.identifier.doi10.1002/jcv2.70092
dc.identifier.issn2692-9384
dc.identifier.urihttp://dx.doi.org/10.1002/jcv2.70092
dc.identifier.urihttps://hdl.handle.net/20.500.14669/4672
dc.identifier.wosWOS:001676278500001
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJCPP Advances
dc.relation.publicationcategoryMakale - Uluslararas� Hakemli Dergi - Kurum ��retim Eleman�
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20260302
dc.subjectALSPAC
dc.subjectdifficult temperament
dc.subjectnetwork analysis
dc.subjectpeer victimisation
dc.subjectpolygenic risk scores
dc.titleUnpacking early risks for peer victimization: A network analysis of early temperament and polygenic risk scores
dc.typeArticle; Early Access

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