A review on three dimensional scaffolds for tumor engineering

dc.authoridceylan, seda/0000-0002-1088-7886
dc.contributor.authorCeylan, Seda
dc.contributor.authorBolgen, Nimet
dc.date.accessioned2025-01-06T17:44:03Z
dc.date.available2025-01-06T17:44:03Z
dc.date.issued2016
dc.description.abstractTwo-dimensional (2D) cell culture and in vivo cancer model systems have been used to understand cancer biology and develop drug delivery systems for cancer therapy. Although cell culture and in vivo model studies have provided critical contribution about disease mechanism, these models present important problems. 2D tissue culture models lack of three dimensional (3D) structure, while animal models are expensive, time consuming, and inadequate to reflect human tumor biology. Up to the present, scaffolds and 3D matrices have been used for many different clinical applications in regenerative medicine such as heart valves, corneal implants and artificial cartilage. While tissue engineering has focused on clinical applications in regenerative medicine, scaffolds can be used in in vitro tumor models to better understand tumor relapse and metastasis. Because 3D in vitro models can partially mimic the tumor microenvironment as follows. This review focuses on different scaffold production techniques and polymer types for tumor model applications in cancer tissue engineering and reports recent studies about in vitro 3D polymeric tumor models including breast, ewing sarcoma, pancreas, oral, prostate and brain cancers.
dc.identifier.doi10.12989/bme.2016.3.3.141
dc.identifier.endpage155
dc.identifier.issn2465-9835
dc.identifier.issn2465-9959
dc.identifier.issue3
dc.identifier.startpage141
dc.identifier.urihttps://doi.org/10.12989/bme.2016.3.3.141
dc.identifier.urihttps://hdl.handle.net/20.500.14669/2896
dc.identifier.volume3
dc.identifier.wosWOS:000392755100002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherTechno-Press
dc.relation.ispartofBiomaterials and Biomechanics in Bioengineering
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241211
dc.subjectpolymeric scaffolds
dc.subject3D tumor models
dc.subjectcancer tissue engineering
dc.subjectin vitro cancer research
dc.titleA review on three dimensional scaffolds for tumor engineering
dc.typeReview Article

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