Identifying the function of methylated genes in Alzheimer's disease to determine epigenetic signatures: a comprehensive bioinformatics analysis

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dc.contributor.authorRahman, Md Rezanur
dc.contributor.authorIslam, Tania
dc.contributor.authorGov, Esra
dc.contributor.authorQuinn, Julian M.W.
dc.contributor.authorMoni, Mohammad Ali
dc.date.accessioned2025-01-06T17:30:11Z
dc.date.available2025-01-06T17:30:11Z
dc.date.issued2021
dc.description.abstractGene methylation is one means of controlling tissue gene expression, but it is unknown what pathways influencing Alzheimer's disease (AD) are controlled this way. We compared normal and AD brain tissue data for gene expression (mRNAs) and gene methylation profiling. We identified methylated differentially expressed genes (MDEGs). Protein-protein interaction (PPI) of the MDEGs showed 18 hypermethylated low-expressed genes (Hyper-LGs) involved in cell signaling and metabolism; also 10 hypomethylated highly expressed (Hypo-HGs) were involved in regulation of transcription and development. Molecular pathways enriched in Hyper-LGs included neuroactive ligand-receptor interaction pathways. Hypo-HGs were notably enriched in pathways including hippo signaling. PPI analysis also identified both Hyper-LGs and Hypo-HGs, as hub proteins. Our analysis of AD datasets identified Hyper-LGs, Hypo-HGs, and transcription factors linked to these genes. These pathways, which may participate in Alzheimer's disease development, may be affected by treatments that influence gene methylation patterns. ©
dc.identifier.doi10.1017/exp.2020.65
dc.identifier.issn2516-712X
dc.identifier.scopus2-s2.0-85137400117
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1017/exp.2020.65
dc.identifier.urihttps://hdl.handle.net/20.500.14669/1501
dc.identifier.volume2
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherCambridge University Press
dc.relation.ispartofExperimental Results
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241211
dc.subjectAlzheimer's disease
dc.subjectbiomarkers
dc.subjectepigenetics
dc.subjectmethylated differentially expressed genes
dc.titleIdentifying the function of methylated genes in Alzheimer's disease to determine epigenetic signatures: a comprehensive bioinformatics analysis
dc.typeArticle

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