Phyllanthus emblica-Loaded Cryogels for Improved Wound Care: Characterization and In Vitro Studies

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dc.contributor.authorCanatar, İpek
dc.contributor.authorÖzdaş, Sibel
dc.contributor.authorBaydemir Peşint, Gözde
dc.date.accessioned2025-01-06T17:29:57Z
dc.date.available2025-01-06T17:29:57Z
dc.date.issued2024
dc.description.abstractWound dressings developed by combining plant extracts with polymers have made a great progress in wound care treatment. One plant with remarkable healing properties is Phyllanthus emblica Linn (P. emblica), which is described as having potent antioxidant, antimicrobial and anti-inflammatory properties. The aim of this study is to evaluate the biocompatibility of P. emblica-loaded polyvinyl alcohol/gelatin-based cryogels (PVA/Gel/P.emblica) through cytotoxicity and proliferation tests in HaCaT cells and examine their potential in wound dressing applications. Accordingly, PVA/Gel/P.emblica cryogels are successfully synthesized and characterization studies and in vitro cell culture studies are performed. The swelling tests and Brunauer–Emmett–Teller analysis results show that swelling and surface area properties of cryogels increase with increasing P. emblica amounts. Morphological results display that the cryogels have a dense, interconnected pore morphology and a macroporous structure. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, trypan blue exclusion, and live–dead assay results reveal that P. emblica enhances cell proliferation, increases cell number, and improves cell viability. Based on the scanning electron microscope, immunofluorescence, and Giemsa staining images, it is observed that P. emblica promotes cell attachment, proliferation, and penetration. These findings confirm that PVA/Gel/P.emblica cryogels are suitable for use as wound dressing materials and can be developed with further studies. © 2024 The Authors. Macromolecular Materials and Engineering published by Wiley-VCH GmbH.
dc.description.sponsorshipAdana Alparslan Türkeş Bilim ve Teknoloji Üniversitesi, ATÜ, (22303016)
dc.identifier.doi10.1002/mame.202300404
dc.identifier.issn1438-7492
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85184508062
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1002/mame.202300404
dc.identifier.urihttps://hdl.handle.net/20.500.14669/1417
dc.identifier.volume309
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc
dc.relation.ispartofMacromolecular Materials and Engineering
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241211
dc.subjectcryogel
dc.subjectPhyllanthus emblica
dc.subjectwound dressing materials
dc.subjectwound healing
dc.titlePhyllanthus emblica-Loaded Cryogels for Improved Wound Care: Characterization and In Vitro Studies
dc.typeArticle

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