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    Composite Cryogels for Drug Delivery Applications: A Preliminary Study with Dye as a Model Drug
    (2023) Demir, Didem; Ceylan, Seda; Bölgen, Nimet
    Cryogels are suitable candidates to be used as drug release systems due to their interconnected pore structures, high surface areas, high liquid absorption capacities, and elasticity. With this purpose, we aimed to produce a cryogel structure to be used in drug release applications with the approach of tissue engineering. As biodegradable and biocompatible polymers chitosan and gelation were selected. The cryogels were fabricated using the combination of these polymers in the presence of glutaraldehyde under cryogenic conditions. The produced optimum gel scaffold was first characterized using FTIR, SEM, porosity, swelling ability, and degradation analyses. Successfully crosslinked gels exhibited an interconnected pore structure with an average pore diameter of 52.95 µm. As a result of the examination of the time-dependent weight change, it was also revealed that the cryogels have a liquid absorption capacity of about 500 times their dry weight and are biodegradable. The mainly characterized cryogel sample was evaluated for potential drug loading and release applications using methyl orange (MO) as a model drug. Gels, which swell in a short time, absorb the dye quickly and the cumulative release of the dye indicates that the gels are suitable for extended-release systems.
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    Öğe
    Influence of fabrication temperature on the structural features of chitosan gels for tissue engineering applications
    (2019) Bölgen, Nimet; Ceylan, Seda; Demir, Didem
    Chitosan is a natural polymer synthesized from the chitin of crab, lobster shells, fungal myceliaand shrimp. It has been used for biomedical applications in many different structures includingthin film, nanofibrous membrane, sponge, microsphere, hydrogel and cryogel because of its nontoxicity, biodegradability, biocompatibility and antibacterial properties. Cryogelation technique isbased on the crosslinking of polymers or crosslinking polymerization of monomers in the presenceof crosslinking agents at temperatures below zero. On the other hand, hydrogels are mainlyprepared at room temperature. In this study, chitosan gels were prepared at different reactiontemperatures (-25, 0 and +25°C). Swelling profiles revealed that with decreasing reactiontemperature swelling ratio increased. In addition, the degradation rate of chitosan gels prepared at-25 and +25°C was measured 50.60 and 30.88%, respectively. Results indicate that reactiontemperature affects the architecture and characterization results of the gels.