PLZF overexpression in T-ALL cell line CEM-C7H2-2C8 downregulates glucocorticoid receptor (GR) and its target genes

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dc.contributor.authorWasım, Muhammad
dc.contributor.authorMansha, Muhammad
dc.contributor.authorTayyab, Muhammad
dc.contributor.authorAwan, Ali Raza
dc.contributor.authorFıryal, Sehrish
dc.contributor.authorMantınger, Christine
dc.contributor.authorYaqub, Tahir
dc.date.accessioned2025-01-06T17:23:49Z
dc.date.available2025-01-06T17:23:49Z
dc.date.issued2014
dc.departmentAdana Alparslan Türkeş Bilim ve Teknoloji Üniversitesi
dc.description.abstractGlucocorticoids (GCs) induce cell cycle arrest and apoptosis in lymphoid cells and constitute a central component in the treatment of lymphoid malignancies. The molecular basis of this clinically important phenomenon remains, however, poorly understood. Using whole genome expression profiling we have previously identified glucocorticoid response genes in children with acute lymphoblastic leukemia (ALL). The promyelocytic leukemia zinc finger (PLZF) appeared as one of the most promising candidate genes, which has been implicated in the pathogenesis of several leukemia types. We have already established that transgenic PLZF reduced the sensitivity to GC-induced apoptosis in the CEM-C7H2-2C8 leukemic cell line and knockdown of PLZF resulted in a small but significant increase in cell death in this cell line. The present study was proposed to find a plausible molecular explanation for this protective effect of PLZF against GC-induced cell death. It was found that doxycycline-regulated PLZF overexpression in the CCRF-CEM T-ALL cell line downregulates the GC-induced GR expression and its target genes, which resulted in reduced apoptosis induced by GC.
dc.identifier.endpage959
dc.identifier.issn1300-0152
dc.identifier.issn1303-6092
dc.identifier.issue6
dc.identifier.startpage956
dc.identifier.trdizinid163208
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/163208
dc.identifier.urihttps://hdl.handle.net/20.500.14669/947
dc.identifier.volume38
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofTurkish Journal of Biology
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241211
dc.titlePLZF overexpression in T-ALL cell line CEM-C7H2-2C8 downregulates glucocorticoid receptor (GR) and its target genes
dc.typeArticle

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