Antibacterial and antioxidant properties and phytochemical screening of Laurus nobilis L. extract from Ethiopia

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dc.contributor.authorBeyene, Rebecca
dc.contributor.authorGeremew, Teshome
dc.contributor.authorDekebo, Aman
dc.date.accessioned2025-01-06T17:22:51Z
dc.date.available2025-01-06T17:22:51Z
dc.date.issued2024
dc.departmentAdana Alparslan Türkeş Bilim ve Teknoloji Üniversitesi
dc.description.abstractMicrobial resistance to antibiotics and the shortage of efficient antimicrobial agent has necessitated the search for a better antimicrobial agent from various sources. Plants secondary metabolites are the major sources for discovery of new bioactive chemical compounds. The objective of this study was to determine the antibacterial and antioxidant activities of Laurus nobilis leaf extract and its essential oil against human pathogenic microorganisms and to analyse its chemical composition. The leaf of L. nobilis (500 g) was air-dried, powdered and extracted using four different solvents. The crude extract and the essential oil were tested against four Gram-negative and two Gram-positive bacterial strains. The radical scavenging activity of the crud extract was examined using DPPH assay. Bacterial inhibition activity of the crude extract increased with increased concentration from 25 mg/mL to 200 mg/mL. The maximum inhibition zone was recorded against Enterococcus faecalis 13.33±1.52 mm, Escherichia coli 14.33±1.53 mm and Salmonella typhimurium 16.00±1.00 mm, respectively. MeOH extract (1000 µg/mL) showed superior radical scavenging property (0.02) than ascorbic acid (0.05). The analysis of the oil using GC-MS indicated the presence of 48 chemical substances accounting for 91.4 % of the total compositions. The finding of this study showed that bay leaf has considerable antimicrobial and antioxidant activities. Further evaluation of this plant is recommended with particular focus on the mechanisms of action of the antimicrobial substance.
dc.identifier.doi10.21448/ijsm.1375324
dc.identifier.endpage506
dc.identifier.issn2148-6905
dc.identifier.issue3
dc.identifier.startpage494
dc.identifier.trdizinid1261069
dc.identifier.urihttps://doi.org/10.21448/ijsm.1375324
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1261069
dc.identifier.urihttps://hdl.handle.net/20.500.14669/504
dc.identifier.volume11
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofInternational Journal of Secondary Metabolite
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241211
dc.subjectEssential oil
dc.subjectAntimicrobial Antioxidant
dc.subjectBay leaf
dc.titleAntibacterial and antioxidant properties and phytochemical screening of Laurus nobilis L. extract from Ethiopia
dc.typeArticle

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