Protective Effect of 5-HTTLPR (S) and VNTR (10) Allele Combinationsof5-HTT Gene Against Adenotonsillary Hypertrophy
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Tarih
2021
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info:eu-repo/semantics/openAccess
Özet
INTRODUCTION: Serotonin transporter protein which is coded by 5HTT gene is responsible forpresynaptic reuptake of serotonin. In this study, we investigated the relationship between polymorphismsin the promoter region (5-HTTLPR) and in the second intron (VNTR) in the 5-HTTgene and adenotonsillarhypertrophy (ATH) in pediatric cases. METHODS: Genotyped of the 5-HTT gene promotor 5-HTTLPR and intronic VNTR of in 197 childrenwere analyzed using Snap Shot, Multifactor Dimensionality Reduction (MDR) software and carried out toassess the interactions among two polymorphisms and phenotype. RESULTS: A total of 119 children with ATH (48 girls, 71 boys age range: 3-10 years; mean age: 5.38years) and 78 healthy children (27 girls, 51 boys, age range: 4-13 years; mean age: 6.76 years) wereincluded in this study. The frequencies of the genotype in all of inheritance models of the 5-HTTLPR andthe VNTR (10) allele showed no significant differences between ATH patient and healthy controls (for allP> 0.05). However, frequency of the 5-HTTLPR (S) allele and VNTR_5-HTTLPR (10/S) haplotype and(10/10+S/S) diplotype were significantly higher in the control group compared to ATH cases (P= 0.048,P= 0.041, P= 0.13). DISCUSSION AND CONCLUSION: In this study, we observed that S/S genotype, 10/S haplotype and10/10 + S/S diplotype of 5-HTT gene could have protective effect against ATH.
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10
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2
