Swelling and mucoadhesive behavior with drug release characteristics of gastoretentive drug delivery system based on a combination of natural gum and semi-synthetic polymers

Basit Öğe Kaydı
dc.contributor.authorBhata, Rita
dc.contributor.authorHossaın, Mohammad Salim
dc.contributor.authorBanık, Sujan
dc.contributor.authorMoghal, Mizanur Rahman
dc.contributor.authorRashid, Mamun Or
dc.contributor.authorAkter, Mariyam
dc.date.accessioned2025-01-06T17:22:36Z
dc.date.available2025-01-06T17:22:36Z
dc.date.issued2018
dc.departmentAdana Alparslan Türkeş Bilim ve Teknoloji Üniversitesi
dc.description.abstractUsing ramipril as a model active pharmaceutical ingredient, the focus of the present study was to fabricatelow-cost controlled release tablets using combinations of biopolymer and semi-synthetic polymers. Cellulose derivativesare more viscous where biopolymers form gels more easily. Xanthan gum can’t shape a solid gel, result in fragmentationof gel around the tablets so that depend upon high concentration. Therefore, a combination was used to formulate tabletby direct compression. This combination of polymer provides low cost product with higher potentiality. Ingredients asper formulations were mixed in small polybag through hand blending. Then tablets were compressed one by one tabletin a hydraulic press. Prepared tablets were evaluated for hardness, weight variation, content uniformity, friability,surface pH and in-vitro dissolution studies. ANOVA was used to analyze the differences between release data. Swellingindex, mucoadhesive strength and in-vitro residence time was studied to show gastroretention of the tablets. Formulatedproducts exhibit sufficient quality and strength to formulate as a mucoadhesive tablet. Significant differences werefound in drug release among different formulations (p ?0.05) in all cases. Among all of formulations, F11, F12 and F13containing different ratio of xanthan gum and guar gum showed promising mucoadhesive strength and in-vitroresidence time.
dc.identifier.doi10.12991/mpj.2018.66
dc.identifier.endpage298
dc.identifier.issn1309-0801
dc.identifier.issue2
dc.identifier.startpage286
dc.identifier.trdizinid326647
dc.identifier.urihttps://doi.org/10.12991/mpj.2018.66
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/326647
dc.identifier.urihttps://hdl.handle.net/20.500.14669/389
dc.identifier.volume22
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofMarmara Pharmaceutical Journal
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241211
dc.subjectKimya
dc.subjectTıbbi
dc.subjectPolimer Bilimi
dc.subjectGıda Bilimi ve Teknolojisi
dc.subjectMalzeme Bilimleri
dc.subjectBiyomalzemeler
dc.titleSwelling and mucoadhesive behavior with drug release characteristics of gastoretentive drug delivery system based on a combination of natural gum and semi-synthetic polymers
dc.typeArticle

Dosyalar

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu