Traditional Medicinal Uses, Phytochemicals, and Pharmacological Activities of Genus Rhamnus: A review

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dc.contributor.authorNigussie, Gashaw
dc.contributor.authorMelak, Haregua
dc.contributor.authorAnnisa, Milkyas Endale
dc.date.accessioned2025-01-06T17:22:43Z
dc.date.available2025-01-06T17:22:43Z
dc.date.issued2021
dc.departmentAdana Alparslan Türkeş Bilim ve Teknoloji Üniversitesi
dc.description.abstractThe genus Rhamnus belongs to the Rhamnaceae family, which contains approximately 137species, traditionally used as folk medicine in East Asia, North and South America, and subtropicalregions of Africa. The genus is used traditionally to treat diseases such as cancer, wound, jaundice,hepatitis, gonorrhea, laxative, hypertension, malaria, stomach ache, snake bite and diarrhea.Anthraquinones and flavonoids are the most cited compounds from the genus of which polyphenols wereabundant with tremendous antioxidant, wound healing and antiinflammatory activities. Pharmacologicalactivity evaluation of the extracts and isolated compounds revealed anti-inflammatory, antioxidant,antimalarial, antibacterial, anti-mutagenic, anti-genotoxic, hepatoprotective, anticancer, and antiproliferative activity. The genus afforded drug leads such as 6-methoxysorigenin (12) and prinoidin (23)with anti-tyrosinase and cytotoxicity, respectively, as well as antioxidant drug leads such as Kaempferol3-O-?-rhamninoside (31) rhamnetin-3-O-?-isorhamninoside (37) and isotorachrysone (55). Thepresent review endeavors to provide a comprehensive and up to date compilation of documentedtraditional medicinal uses, phytochemicals and pharmacological activities of the genus and providedvaluable information in support of its uses as an alternative medicine for future healthcare practice.
dc.identifier.doi10.18596/jotcsa.929188
dc.identifier.endpage932
dc.identifier.issn2149-0120
dc.identifier.issue3
dc.identifier.startpage899
dc.identifier.trdizinid451082
dc.identifier.urihttps://doi.org/10.18596/jotcsa.929188
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/451082
dc.identifier.urihttps://hdl.handle.net/20.500.14669/474
dc.identifier.volume8
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofJournal of the Turkish Chemical Society, Section A: Chemistry
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241211
dc.subjectRhamnus
dc.subjectflavonoids
dc.subjectanthraquinones
dc.subjectpharmacological activities
dc.titleTraditional Medicinal Uses, Phytochemicals, and Pharmacological Activities of Genus Rhamnus: A review
dc.typeReview Article

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