An Overview of Synthetic Derivatives of Thiazole and Their Role in Therapeutics

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dc.contributor.authorKashyap, Manoj
dc.contributor.authorMazumder, Muslek Uddin
dc.contributor.authorPatowary, Pooja
dc.contributor.authorTalukdar, Apurba
dc.contributor.authorSaharıah, Bhargab Jyoti
dc.contributor.authorMajumder, Manish
dc.date.accessioned2025-01-06T17:23:37Z
dc.date.available2025-01-06T17:23:37Z
dc.date.issued2024
dc.departmentAdana Alparslan Türkeş Bilim ve Teknoloji Üniversitesi
dc.description.abstractThiazole derivatives have attracted much attention in medicinal chemistry due to their diverse pharmacological activities. This study provides an overview of the latest synthetic derivatives of thiazole and their therapeutic applications. Innovative methodologies have been adopted to enhance the structural diversity and optimize the pharmacological properties of thiazolebased compounds. These synthetic derivatives exhibit a broad spectrum of therapeutic activities, and understanding the essential features responsible for the observed pharmacological effects has been pivotal in structureactivity relationship studies. Drug development efforts have focused on modulating thiazole derivatives for improved bioavailability, selectivity, and reduced toxicity. This abstract highlights the potential of thiazole derivatives in targeting specific biological activity, paving the way for developing innovative therapeutic agents. Thiazole moiety as a heterocyclic compound was studied for its different pharmacological actions. The derivatives obtained from thiazole have diverse therapeutic actions along with antimicrobial activity, antitubercular activity, antidiabetic activity, anticonvulsant, anti-inflammatory actions, and antitumor activities. The mechanism of actions of all these activities is also studied by the researcher to provide scientific evidence and validation of their actions. Utilization of synthetic chemistry for exploration of various pharmacological potential of thiazole derivatives will lead the future pharmacologists to a newer dimension for new drug discovery and also these derivatives can be further optimized for the development of alternative options for the treatment of various diseases. The versatility of thiazole scaffolds presents promising opportunities for discovering new drugs with enhanced efficacy and improved pharmacokinetic profiles. As researchers continue to delve into the synthesis and pharmacological evaluation of thiazole derivatives, their significance in modern drug design and therapy becomes increasingly evident.
dc.identifier.doi10.55262/fabadeczacilik.1479735
dc.identifier.endpage626
dc.identifier.issn1300-4182
dc.identifier.issn2651-4648
dc.identifier.issue3
dc.identifier.startpage603
dc.identifier.trdizinid1275143
dc.identifier.urihttps://doi.org/10.55262/fabadeczacilik.1479735
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1275143
dc.identifier.urihttps://hdl.handle.net/20.500.14669/861
dc.identifier.volume49
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofFABAD Journal of Pharmaceutical Sciences
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241211
dc.subjectAntimicrobial
dc.subjectanti-inflammatory
dc.subjectheterocyclic
dc.subjectThiazole
dc.subjectantitubercular
dc.titleAn Overview of Synthetic Derivatives of Thiazole and Their Role in Therapeutics
dc.typeReview Article

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