Cardioprotective Effect of Pistacia vera L. (Green Pistachio) Hull Extract in Wistar Albino Rats with Doxorubicin-Induced Cardiac Damage

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dc.contributor.authorErsöz, Ezhar Korkmaz
dc.contributor.authorAydın, Mehmet Salih
dc.contributor.authorHacanlı, Yasemin
dc.contributor.authorKankılıç, Nazım
dc.contributor.authorKoyuncu, İsmail
dc.contributor.authorGüldür, Muhammet Emin
dc.contributor.authorTemiz, Ebru
dc.date.accessioned2025-01-06T17:22:36Z
dc.date.available2025-01-06T17:22:36Z
dc.date.issued2023
dc.departmentAdana Alparslan Türkeş Bilim ve Teknoloji Üniversitesi
dc.description.abstractBackground: Pistacia vera L. (green pistachio) has been shown to increase antioxidant capacity and protect against cardiovascular diseases and cancer. This study investigated the protective effect of the Pistacia vera L. hull in rats with experimental cardiac damage induced by doxorubicin. Methods: Sixty adult Wistar albino rats were randomly divided into 5 groups (n=12). Sham, doxorubicin, doxorubicin + Pistacia vera L. extract 50 mg/kg, doxorubicin + Pistacia vera L. extract 100 mg/kg, and Pistacia vera L. extract 100 mg/kg. Biochemistry param- eters, total antioxidant status, total oxidant status, oxidative stress index, 8-hydroxy- deoxyguanosine, and caspase 3/7 values were measured in serum samples. Excised heart tissues were examined histopathologically. Results: The groups were statistically significantly different in 8-hydroxy-deoxyguanosine, caspase 3/7, total antioxidant status, total oxidant status, oxidative stress index, and basal biochemical parameter values (P < .05, P < .001). In group II, 8-hydroxy-deoxyguanosine, caspase 3/7, and total oxidant status values increased while the total antioxidant status value decreased (P < .001). In the treatment groups (group III and group IV), 8-hydroxy- deoxyguanosine and caspase 3/7 values decreased compared to group II (P < .001). While total oxidant status and oxidative stress index values decreased in the treatment groups, total antioxidant status values increased (P < .001). The histopathological examination of the heart revealed fewer areas of focal necrosis in the treatment groups compared to group II. Conclusion: In this study, the cardioprotective effect of Pistacia vera L. hull extract was investigated in vivo. It was shown that Pistacia vera L. hull extract reduced apoptosis and deoxyribonucleic acid damage in the face of cardiac damage and had antioxidant activ- ity. Future studies will increase our knowledge on this subject.
dc.identifier.doi10.14744/AnatolJCardiol.2022.2452
dc.identifier.endpage145
dc.identifier.issn2149-2263
dc.identifier.issn2149-2271
dc.identifier.issue3
dc.identifier.startpage135
dc.identifier.trdizinid1168696
dc.identifier.urihttps://doi.org/10.14744/AnatolJCardiol.2022.2452
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1168696
dc.identifier.urihttps://hdl.handle.net/20.500.14669/393
dc.identifier.volume27
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofThe Anatolian Journal of Cardiology
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241211
dc.subjectTıbbi Araştırmalar Deneysel
dc.subjectGenel ve Dahili Tıp
dc.subjectPatoloji
dc.subjectViroloji
dc.subjectBiyokimya ve Moleküler Biyoloji
dc.subjectKalp ve Kalp Damar Sistemi
dc.titleCardioprotective Effect of Pistacia vera L. (Green Pistachio) Hull Extract in Wistar Albino Rats with Doxorubicin-Induced Cardiac Damage
dc.typeArticle

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