The common genetic variants of toll-like receptor and susceptibilityto adenoid hypertrophy: a hospital-based cohort study

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dc.contributor.authorBabademez, Mehmet Ali
dc.contributor.authorÖzdaş, Talih
dc.contributor.authorÖzdaş, Sibel
dc.date.accessioned2025-01-06T17:24:01Z
dc.date.available2025-01-06T17:24:01Z
dc.date.issued2016
dc.departmentAdana Alparslan Türkeş Bilim ve Teknoloji Üniversitesi
dc.description.abstractBackground/aim: Adenoid hypertrophy (AH) is one of the most frequent pediatric disorders. The aim of this study was to investigate the effects of TLR2-R753Q, TLR4-T399I, and TLR4-D299G polymorphisms in children with AH. Materials and methods: The variants of the TLR gene were determined by restriction fragment length polymorphism (PCR-RFLP) analysis in 60 patients with AH and in 50 healthy children. Data were analyzed with SNPStats and multifactor dimensionality reduction (MDR) software. Results: We found that the presence of the G allele, the AG+GG and AG genotypes at TLR4-D299G, and the GGT haplotype were associated with AH in children (P = 0.013, P = 0.02, P = 0.038, and P = 0.001, respectively). On the contrary, no association was found between TLR2-R753Q and predisposition to AH. The CT genotype at TLR4-T399I showed a sex-specific association with AH, occurring only in boys with allergies (P = 0.0048). In addition, MDR analysis indicated a strong synergy between TLR gene markers contributing to AH. Allergic children with the diplotypes that included minor alleles of TLR4-D299G or TLR4-T399I had about a 4-fold increased risk for AH. Conclusion: Common genetic variants of the gene encoding the TLR4 protein may have differential effects on AH and the presence of sex-specific allergy.
dc.identifier.endpage1458
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue5
dc.identifier.startpage1449
dc.identifier.trdizinid252257
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/252257
dc.identifier.urihttps://hdl.handle.net/20.500.14669/1029
dc.identifier.volume46
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241211
dc.titleThe common genetic variants of toll-like receptor and susceptibilityto adenoid hypertrophy: a hospital-based cohort study
dc.typeArticle

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