Yazar "Tuncsoy, Mustafa" seçeneğine göre listele

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    Green synthesis of silver nanoparticles using carob leaf extract: Characterization and analysis of toxic effects in model organism Galleria mellonella L. (The greater wax moth)
    (Springer, 2024) Andırın, Aslıhan; Yaycı, Nur Dudu; Idikut, Murat; Kara, Ayse; Tuncsoy, Mustafa; Tuncsoy, Benay; Ozalp, Pınar
    Silver nanoparticles (Ag NPs) have been used in many studies due to their inhibitory properties on microorganisms such as bacteria and viruses. In recent years, due to global problems such as environmental pollution, the green synthesis (biosynthesis) method is frequently preferred because it is simple and low cost and does not require the use of toxic substances. The aim of this study is to synthesize silver nanoparticles (Ag NPs) from Ceratonia siliqua L. leaves and investigate their antioxidant and immunotoxic properties using Galleria mellonella last instar larvae. The UV spectrophotometer, TEM, XRD and FTIR measurements were used to characterize the Ag NPs. In this study, it was determined that the effects on antioxidant enzyme activities (SOD, CAT, GPx, GST), acetylcholinesterase (AChE) and total hemocyte count (THC) as well as phenoloxidase activity determine their effect on antioxidant defence and the immune system in model organism G. mellonella larvae. We observed that green synthesized Ag NPs accumulate in the midgut of the larvae and led to the increasing of CAT and SOD activities. GST and AChE activities were increased in the fat body of the larvae; otherwise, it was decreased in the midgut. Moreover, increases were found in THC and phenoloxidase activity. Consequently, green synthesized silver nanoparticles led to oxidative stress and immunotoxic effects on G. mellonella larvae. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.
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    Particle Size Effect of Micro and Nano Aluminium Oxides on Antioxidant Defence System of Model Organism Galleria mellonella
    (Springer, 2023) Tuncsoy, Benay; Tuncsoy, Mustafa
    Studies on heavy metal toxicity show that toxicity of nanoparticles compared to micro form have hypothesis regarding nanoparticles are more efficient on the oxidative stress. The aim of the study was to compare the toxic effects of nano and micro particles of Al2O3 and tissue differences on oxidative stress using model organism Galleria mellonella larvae. The study presented that Al2O3 NPs increased the antioxidant enzyme activities in the fat body of larvae, whereas Al2O3 MPs increased the enzyme activities in the midgut of larvae. In conclusion, heavy metal toxicity depends on the particle size, as well as tissue differences.
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    Toxicological Effects of Nanomaterials in Terrestrial and Aquatic Insects
    (Springer International Publishing, 2023) Tuncsoy, Benay; Tuncsoy, Mustafa
    Nanomaterials of different sizses and diameters are frequently used in various industrial areas, due to the rapid development of nanotechnology. Hence, it leads to toxic effects on the environment and non-target organisms. Due to the increasing use of nanotechnology in the industrial field, it is inevitable that the rate of release of engineered and natural nanomaterials in the atmosphere increases. This makes it important to investigate the effects of the developing industrial product on the environment, human, animal, and plant health. In recent studies, it has been revealed that nanomaterials taken into the organism especially by respiratory tract are densely accumulated in cells and tissues due to their small size compared to other bulk materials. Due to the release of nanomaterials to the environment through emissions and commercial products, they reach wastewater treatment plants and surface water, posing a major threat to the environment and non-target organisms. Insects are groups of living things that make up a large population of both aquatic and terrestrial environments. Bioaccumulation and biomagnification of nanomaterials are of great importance in these living groups. Bioaccumulation of nanomaterials begins with the accumulation of nanoparticles in the organism and is then transferred to other organisms through the food chain. Therefore, both aquatic and terrestrial insects constitute an important part of this chain. This chapter will focus on the toxicological effects of nanomaterials on terrestrial and aquatic insects and their impacts on human and environmental safety. © Springer Nature Switzerland AG 2023.