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    Determination of antimicrobial and antiviral properties of IR3535
    (Springer, 2019) Iyigundogdu, Zeynep; Kalayci, Sadik; Asutay, Ayla Burcin; Sahin, Fikrettin
    Insect repellent is a substance directly applied to skin or clothing in order to repel flies, mosquitoes, ticks etc. IR3535 or Ethyl butylacetylaminopropionate (EBAAP) is a relatively new repellent which is classified as a biopesticide due to exceptional skin tolerance and overall safety. The repellency against various insect and ticks, and the low toxicity of IR3535 are well acknowledged. However, there has been no attempt to investigate the effects on microorganisms or viruses up to now. In the present study, antimicrobial activity was investigated based on disc diffusion and micro-well dilution assays. Disc diffusion assays revealed IR3535 displayed remarkable antimicrobial activity on the microorganisms tested. MIC results showed that the antifungal efficiency of IR3535 is higher with respect to its antibacterial and anticandidal efficiency. Moreover, antiviral test results revealed that IR3535 showed antiviral effects against Poliovirus and Adenovirus. This is the first study that reveals IR3535's antimicrobial and antiviral properties against a broad range of microorganisms and viruses. In consideration of the antimicrobial and antiviral properties, IR3535 is a promising agent that could be used to develop novel therapeutic approaches, new application areas and formulations in the future.
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    Developing Novel Antimicrobial and Antiviral Textile Products
    (Springer, 2017) Iyigundogdu, Zeynep Ustaoglu; Demir, Okan; Asutay, Ayla Burcin; Sahin, Fikrettin
    In conjunction with an increasing public awareness of infectious diseases, the textile industry and scientists are developing hygienic fabrics by the addition of various antimicrobial and antiviral compounds. In the current study, sodium pentaborate pentahydrate and triclosan are applied to cotton fabrics in order to gain antimicrobial and antiviral properties for the first time. The antimicrobial activity of textiles treated with 3 % sodium pentaborate pentahydrate, 0.03 % triclosan, and 7 % Glucapon has been investigated against a broad range of microorganisms including bacteria, yeast, and fungi. Moreover, modified cotton fabrics were tested against adenovirus type 5 and poliovirus type 1. According to the test results, the modified textile goods attained very good antimicrobial and antiviral properties. Thus, the results of the present study clearly suggest that sodium pentaborate pentahydrate and triclosan solution-treated textiles can be considered in the development of antimicrobial and antiviral textile finishes.
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    Efficacy of a newly developed seed coating formulation for the control of seed-borne diseases
    (Tubitak Scientific & Technological Research Council Turkey, 2022) Bouri, Meriain; Iyigundogdu, Zeynep; Lok, Pinar; Sahin, Fikrettin
    Seed coating is receiving increased relevance in sustainable agriculture, to reduce the usage of pesticides and protect the natural environment. In this study, a new formulation based on the combination of two active constituents (zinc pyrithione and triclosan) and an inactive component (carboxymethyl cellulose polymer) was optimized for seed coating to control seed-borne pathogens. According to the in vitro antimicrobial tests, the combination of zinc pyrithione and triclosan showed a broader spectrum of phytopathogenic bacteria and fungi control. Coated seeds from different plant species with 2% of zinc pyrithione, 0.05% of triclosan and, 0.5% of carboxymethyl cellulose did not show any microorganisms development on culture media, contrarily to the noncoated ones. Germination quality and seedling growth of treated groups were enhanced in the presence of natural seed-borne pathogens and not affected in pathogen-free seeds compared to the nontreated groups. Thus, this novel seed coating formulation is a promising antimicrobial agent that could be used in the prevention of seed-borne diseases without any side effect on the seedling establishment.
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    Öğe
    Long-term durability of thermoplastic elastomer containing antiviral additives for mobility applications
    (Wiley, 2024) Iyigundogdu, Zeynep; Couvreur, Rachel; Tamrakar, Sandeep; Yoon, Jaewon; Basar, Basak; Ersoy, Osman G.; Sahin, Fikrettin
    In the mobility market, there is a demand from customers for antimicrobial protection. As a result, the market has grown considerably to provide antiviral and antimicrobial polymers and coatings. This study examines how the efficacy of a non-commercial antimicrobial thermoplastic elastomer will change over the life of the application. Using an example application of an electric scooter handlebar grip, durability requirements were identified, and antiviral efficacy (exceeding a log value of 3 or >99.9 microbial growth reduction) was compared before and after testing. A scooter handlebar grip was selected as the ideal example application as it was a high-touch surface, with several different riders. During the start of this study, scooter companies were encouraging their riders to disinfect scooter handlebars before riding, use hand sanitizer, and wear gloves. If the handlebar grip could be antimicrobial, then they could eliminate these steps and provide a safe ride for the users. In order to simulate long-term durability, UV exposure, temperature, humidity, artificial sweat, sunscreen, insect repellent, and abrasion tests were performed and evaluated in terms of antiviral activity. Accelerated weathering reduced the virucidal activity of the sample versus unexposed antiviral thermoplastic elastomer (TPE). However, the efficacy increased with contact time from 90% to 96.83% at 30 and 120 min, respectively. Abrasion resistance of antiviral TPE showed a volume loss of 66 mm3 compared to control samples of 83 mm3. The antiviral TPE sample exhibited slightly lower efficacy compared to the control after exposure to the artificial sweat (99.43% vs. 99.95%). Additionally, a skin tolerance test conducted on rabbits showed that antiviral TPE was not an irritant and showed no dermal toxicity. The outcome of this study will lead to the development of long-term durable antimicrobial material for the transportation industry.
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    Öğe
    Thermoplastic elastomers containing antimicrobial and antiviral additives for mobility applications
    (Elsevier Sci Ltd, 2022) Iyigundogdu, Zeynep; Basar, Basak; Couvreur, Rachel; Tamrakar, Sandeep; Yoon, Jaewon; Ersoy, Osman G.; Sahin, Fikrettin
    The transmission of the SARS-CoV-2 coronavirus has been shown through droplets generated by infected people when coughing, sneezing, or talking in close contact. These droplets either reach the next person directly or land on nearby surfaces. The objective of this study is to develop a novel, durable, and effective disinfecting antimicrobial (antiviral, antibacterial, and antifungal) styrene-ethylene/butylene-styrene (SEBS) based thermoplastic elastomers (TPE). TPE incorporated with six different formulations was investigated for mechanical and antiviral performance. The formulations consist of a combination of zinc pyrithione (ZnPT), sodium pentaborate pentahydrate (NaB), disodium octaborate tetrahydrate (DOT), and chlorhexidine (CHX). ZnPT and DOT incorporated TPE showed a reduction of microbes such as bacteria by up to 99.99%, deactivated Adenovirus, Poliovirus, Norovirus, and reduced a strain of the coronavirus family by 99.95% in 60 min on TPE samples. Control samples had higher tensile strengths among all formulations and tensile strength decreased by around 14%, 21% and 27% for ZnPT and DOT combinations compared to control samples. The elongation at break decreased by around 7%, 9% and 12% with ZnPT and DOT combinations, where it reached minimum values of 720%, 702% and 684%, respectively. The 100% Modulus and 300% Modulus slightly increased with ZnPT and NaB combination (reaching values from 1.6 to 1.9 MPa and 2.6-2.9 MPa respectively) in comparison with control samples. The MFI also decreased with antimicrobial and antiviral additives (decreasing values from 64.8 to 43.3 g/10 min). ZnPT and NaB combination showed the lowest MFI (43.3 g/10 min) and reduced the MFI of control sample by around 33%. TPE samples containing ZnPT and DOT combination showed biocidal activity against the microorganisms tested and can be used to develop antimicrobial products for multiple touchpoints within a vehicle and micro-mobility.