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    A bi-layer electrospun polyurethane/silicone membrane scaffold: drug delivery and cytotoxicity studies
    (Indian Acad Sciences, 2023) Mohsenzadeh, Elham; Demir, Didem; Ceylan, Seda; Khenoussi, Nabyl; Schacher, Laurence; Adolphe, Dominique; Bolgen, Nimet
    In this study, a bi-layer scaffold combining polyurethane nanofibrous and silicone membrane layers was produced. Chemical, morphological and physical properties of the scaffolds were determined by Fourier-transform infrared spectroscopy, scanning electron microscope (SEM) and Brunauer-Emmett-Teller analyses, respectively. The surface properties were examined with the contact angle test. To evaluate the encapsulation and release behaviour of the scaffolds Rhodamine B and Nile red were used as model drugs. Further, the cytotoxicity and cell proliferation investigations were carried out using mouse embryonic fibroblasts cell lines. 3-(4,5-dimethylthiazoyl-2-yl)-2,5-diphenyltetrazolium bromide assay and SEM were used to investigate the cell viability and cell-scaffold interactions, respectively. The results of the study were evaluated in order to develop a bimodal drug release system that has the potential to be used in tissue engineering applications.