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    Applying data mining techniques to predict vitamin D deficiency in diabetic patients
    (Sage Publications Inc, 2023) Essiz, Ugur Engin; Yuregir, Oya Hacire; Sarac, Esra
    Vitamin D is among the vitamins necessary for both adults' and children's health. It plays a significant role in calcium absorption, the immune system, cell proliferation and differentiation, bone protection, skeletal health, rickets, muscle health, heart health, disease pathogenesis and severity, glucose metabolism, glucose intolerance, varying insulin secretion, and diabetes. Because the 25-hydroxyvitamin D (25OHD) test, which is used to measure vitamin D is expensive and may not be covered in healthcare benefits in many countries, this study aims to predict vitamin D deficiency in diabetic patients. The prediction method is based on data mining techniques combined with feature selection by using historical electronic health records. The results were compared with a filter-based feature selection algorithm, namely relief-F. Non-valuable features were eliminated effectively with the relief-F feature selection method without any performance loss in classification. The performances of the methods were evaluated using classification accuracy (ACC), sensitivity, specificity, F1-score, precision, kappa results, and receiver operating characteristic (ROC) curves. The analyses have been conducted on a vitamin D dataset of diabetic patients and the results show that the highest classification accuracy of 97.044% was obtained for the support vector machines (SVM) model using radial kernel that contains 18 features.
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    Öğe
    Deep Learning-Based Prediction Models for theDetection of Vitamin D Deficiency and25-Hydroxyvitamin D Levels Using Complete BloodCount Tests
    (Editura Acad Romane, 2024) Essiz, Ugur Engin; Aci, Cigdem Inan; Sarac, Esra; Aci, Mehmet
    Vitamin D (VitD) is an essential nutrient that is critical for the well-being of both adults and children, and its deficiency is recognized as a precursor to several diseases. In previous studies, researchers have approached the problem of detecting vitamin D deficiency (VDD) as a single sufficient/deficient classification problem using machine learning or statistics-based methods. The main objective of this paper is to predict a patient's VitD status (i.e., sufficiency, insufficiency, or deficiency), severity of VDD (i.e., mild, moderate, or severe), and 25-hydroxyvitamin D (25(OH)D) level in a separate deep learning (DL)-based models. An original dataset consisting of complete blood count (CBC) tests from 907 patients, including 25(OH)D concentrations, collected from a public health laboratory was used for this purpose. CNN, RNN, LSTM, GRU and Auto-encoder algorithms were used to develop DL-based models. The top 25 features in the CBC tests were carefully selected by implementing the Extra Trees Classifier and Multi-task LASSO feature selection algorithms. The performance of the models was evaluated using metrics such as accuracy, F1-score, mean absolute error, root mean square error and R-squared. Remarkably, all three models showed satisfactory results when compared to the existing literature; however, the CNN-based prediction models proved to be the most successful.