Ozdas, Sibel2025-01-062025-01-0620182149-21232148-417110.17350/HJSE19030000105https://doi.org/10.17350/HJSE19030000105https://search.trdizin.gov.tr/tr/yayin/detay/382701https://hdl.handle.net/20.500.14669/432Sinonasal polyposis (SP) is an inflammatory disease involving multiple etiologies andpathogenesis. The disarray of Interleukin (IL)-10 is associated with a raised immunopathologicalresponse during the progression of many autoimmune diseases as well as theresponse to infection. We studied the possible role of the single nucleotide polymorphisms(SNPs) in IL-10 gene and their genotypic combinations in the SP pathogenesis. The IL-10’spromoter was genotyped in 200 participants (100 patients and 100 controls). The sites thatwere encompassed -1082, -819, and -592 SNP regions of extracted DNAs were analyzedby sequencing for polymorphisms. The IL-10 gene promoter polymorphisms with -1082A,-819T, -592A minor alleles, their heterozygotes and homozygotes mutant genotypes hadsignificantly higher risks for SP (P<0.05). Also, haplotype analysis demonstrated that theGTC, ACC, and GCA haplotypes in IL-10 were high-risk of SP but ATA was only incontrols (P= 0.007). Also, the multifactor dimensionality reduction (MDR) analysis indicatedthat the IL-10-1082_-819 and -1082_-819_-592 were the best predictive modelsfor SP with 66.6% and 69% accuracy, respectively. IL-10 genotypic variations and theircombinations are linked with a high-risk for the SP development in the Turkish population.The IL-10 genetic polymorphisms may lend to SP by altering the arrangement of the geneexpression, affecting the severity of the inflammatory response.eninfo:eu-repo/semantics/openAccessGenetik ve KalıtımBiyokimya ve Moleküler BiyolojiİmmünolojiArticle29242853827015