Elattar, Khaled M.Mert, Basak DogruMonier, M.El-Mekabaty, Ahmed2025-01-062025-01-0620202046-206910.1039/d0ra00411a2-s2.0-85084058501https://doi.org/10.1039/d0ra00411ahttps://hdl.handle.net/20.500.14669/3253Heterocycles incorporating a pyrimidopyrimidine scaffold have aroused great interest from researchers in the field of medical chemistry because of their privileged biological activities; they are used as anti-bacterial, antiviral, anti-tumor, anti-allergic, antihypertensive, anticancer, and hepatoprotective agents. Therefore, the present study aims to investigate the chemistry of heterocycles incorporating pyrimido[1,6-a]pyrimidine and pyrimido[1,6-c]pyrimidine skeletons and their biological characteristics. The main sections discuss (1) the synthetic routes to obtain substituted pyrimidopyrimidines, pyrimido[1,6-a]pyrimidin-diones, pyrimidoquinazolines, tricyclic, tetracyclic, and binary systems; (2) the reactivity of the substituents attached to the pyrimidopyrimidine skeleton, including thione and amide groups, nucleophilic substitutions, condensations, ring transformations, and coordination chemistry; (3) compounds of this class of heterocycles containing a significant characteristic scaffold and possessing a wide range of biological characteristics.eninfo:eu-repo/semantics/openAccessEndothelıal Growth-FactorPyrımıdıne-DerıvatıvesCondensed HeterocyclesInhıbıtorsChemıstryQuınazolınesDesıgnPotentCyclızatıonAntagonıstsReview Article154922635558641Q11546110WOS:000530037900047Q2