Monier, MohamedAbdel-Latif, DoaaEl-Mekabaty, AhmedMert, Basak D.Elattar, Khaled M.2025-01-062025-01-0620191570-17941875-627110.2174/15701794166661907041136472-s2.0-85073961020https://doi.org/10.2174/1570179416666190704113647https://hdl.handle.net/20.500.14669/2934The aim of this work is to discuss the chemistry of pyrido[3,4-d]pyrimidines as one of the most important heterocyclic compounds with remarkable synthetic, biological and medical applications. In this overview, the chemistry of hetemcyclic compounds incorporated the pyrido[3,4-d]pyrimidine scaffold as demonstrated by chemical reactions and different preparation processes. The anticipated compounds were synthesized from pyridine or pyrimidine compounds and a description of the reactivity of substituents attached to ring carbon and nitrogen atoms is discussed. On the other hand, the synthesis and reactions of fused heterocycles incorporated pyrido[3,4-d]pyrimidine scaffold is described. The diamine analogs included pyrido[3,4-d]pyrimidine core were reported as tyrosine kinase inhibitors. The chemical reactions of certain unexpected and chemically substantial compounds have been discussed.eninfo:eu-repo/semantics/closedAccessPyrido[3,4-d]pyrimidinessubstituents' reactivitysynthetic routesbiological applicationsheterocyclic compoundstyrosine kinase inhibitorsReview Article854631984909Q381216WOS:000499095900001Q3