Monier, M.El-Mekabaty, AhmedAbdel-Latif, DoaaMert, Baak DogruElattar, Khaled M.2025-01-062025-01-0620200039-128X1878-586710.1016/j.steroids.2019.1085482-s2.0-85076310913https://doi.org/10.1016/j.steroids.2019.108548https://hdl.handle.net/20.500.14669/3067Steroids are components of cell membranes, signaling molecules and are a type of secondary metabolites as a result of their high impact of biological significance. The present review described the literature reports of pentacyclic steroidal pyrimidines as a type of heterocyclic steroids. The main sections included the synthesis of the investigated steroids fused at rings-A or B or D of steroid skeleton, synthesis of binary or linked-type pyrimidines, pyrimidine oxides, macromolecules and mono- or di- or hi-peptides linked-steroidal pyrimidines. Besides, the present research highlighted the biological significance of steroidal pyrimidines, in which the compounds revealed potent anticancer, antioxidant, antibacterial, and anti-Alzheimer agents. In addition, some hetero-steroids were screened for binding DNA assay and gene expression analysis. It was settled that the incorporation of pyrimidine scaffold into steroid basic skeleton is crucial for better biological results.eninfo:eu-repo/semantics/closedAccessSteroidal-pyrimidinesPentacyclic systemsSynthetic methodsReactivityBiological activitiesReview Article31805293Q2154WOS:000513293100002Q3