Tuncsoy, MustafaTuncsoy, Benay2026-02-272026-02-2720260007-48611432-080010.1007/s00128-025-04178-8http://dx.doi.org/10.1007/s00128-025-04178-8https://hdl.handle.net/20.500.14669/4659Aluminum (Al) is a widely occurring element in nature and is the most abundant element in the earth's crust after oxygen and silicon. In this study, metal accumulation levels in the gills, liver and muscle tissues and liver SOD, CAT and GPx enzyme activities of liver tissue of O. niloticus were determined under the influence of 10 mg/L concentrations of micro and nano sizes of Al2O3 for 7 days. Aluminum levels in the tissues were measured by ICP-MS. In this study, no mortality was observed during the experiments. It was observed that there was a significant increase in the tissues examined under the effect of both forms of Al2O3 compared to the control. At the end of the 7 days exposure period, the following relationship was found among the tissues in accumulating under the effect of both forms of Al2O3 as gill > liver > muscle. It was also observed that there was a significant increase in SOD, CAT and GPx enzyme activities of liver tissue examined under the effect of both forms of Al2O3 compared to the control. Overall, Al2O3 NPs are more effective than Al2O3 MP in terms of liver enzyme activities.eninfo:eu-repo/semantics/closedAccessSizeMicroNanoAluminumAccumulationAntioxidant enzymesO. niloticusArticle141537973116WOS:001663174400002