Bhata, RitaHossaın, Mohammad SalimBanık, SujanMoghal, Mizanur RahmanRashid, Mamun OrAkter, Mariyam2025-01-062025-01-0620181309-080110.12991/mpj.2018.66https://doi.org/10.12991/mpj.2018.66https://search.trdizin.gov.tr/tr/yayin/detay/326647https://hdl.handle.net/20.500.14669/389Using ramipril as a model active pharmaceutical ingredient, the focus of the present study was to fabricatelow-cost controlled release tablets using combinations of biopolymer and semi-synthetic polymers. Cellulose derivativesare more viscous where biopolymers form gels more easily. Xanthan gum can’t shape a solid gel, result in fragmentationof gel around the tablets so that depend upon high concentration. Therefore, a combination was used to formulate tabletby direct compression. This combination of polymer provides low cost product with higher potentiality. Ingredients asper formulations were mixed in small polybag through hand blending. Then tablets were compressed one by one tabletin a hydraulic press. Prepared tablets were evaluated for hardness, weight variation, content uniformity, friability,surface pH and in-vitro dissolution studies. ANOVA was used to analyze the differences between release data. Swellingindex, mucoadhesive strength and in-vitro residence time was studied to show gastroretention of the tablets. Formulatedproducts exhibit sufficient quality and strength to formulate as a mucoadhesive tablet. Significant differences werefound in drug release among different formulations (p ?0.05) in all cases. Among all of formulations, F11, F12 and F13containing different ratio of xanthan gum and guar gum showed promising mucoadhesive strength and in-vitroresidence time.eninfo:eu-repo/semantics/openAccessKimyaTıbbiPolimer BilimiGıda Bilimi ve TeknolojisiMalzeme BilimleriBiyomalzemelerArticle298228632664722