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Browsing by Author "Ozdas, Sibel"

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Association of Toll-Like Receptor Polymorphisms With Nasal Polyposis

Kesici, Gulin Gokcen; Kaytez, Kargin Selda; Ozdas, Talih; Ozdas, Sibel (ENT-EAR NOSE & THROAT JOURNAL / SAGE PUBLICATIONS INC., 2021-01)

Nasal polyposis is a disease characterized with chronic inflammation of the nasal mucosa. Toll-like receptors (TLRs) are defined as essential receptors of the innate immune system and may play in the development of nasal ...
Association of Ugrp2 gene polymorphisms with adenoid hypertrophy in the pediatric population

Atilla, Mahmut Hunturk; Ozdas, Sibel; Ozdas, Talih; Bastimur, Sibel; Muz, Sami Engin; Oz, Isilay; Kurt, Kenan; Izbirak, Afife; Babademez, Mehmet Ali; Vatandas, Nilgun (BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY / ASSOC BRASILEIRA OTORRINOLARINGOLOGIA & CIRURGIA CERVICOFACIAL, 2018-09)

Introduction: Adenoid hypertrophy is a condition that presents itself as the chronic enlargement of adenoid tissues; it is frequently observed in the pediatric population. The Ugrp2 gene, a member of the secretoglobin ...
Crm1 knockdown by specific small interfering RNA reduces cell proliferation and induces apoptosis in head and neck cancer cell lines

Ozdas, Sibel; Ozdas, Talih (TURKISH JOURNAL OF BIOLOGY / TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, 2018)

Head and neck squamous cell carcinoma (HNSCC) is the most common and most aggressive type of head and neck cancer. Current approaches for the treatment of HNSCC are not sufficient to increase the patient survival or to ...
Knockdown of SET Domain, Bifurcated 1 suppresses head and neck cancer cell viability and wound-healing ability in vitro

Ozdas, Sibel (TURKISH JOURNAL OF BIOLOGY / TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, 2019-12)

Head and neck cancer (HNC) is the sixth most common cancer worldwide and therefore presents a global public health problem. There are no standard algorithms for the diagnosis and follow-up of the disease, and no effective ...
Nuclear entrapment of p33(ING1b) by inhibition of exportin-1: A trigger of apoptosis in head and neck squamous cell cancer

Ozdas, Sibel (CELLULAR AND MOLECULAR BIOLOGY / C M B ASSOC, 2018-04)

The effect of deregulation of nuclear export mediated by exportin-L with consequent cellular mislocalization of p33(ING1b), a member of the tumor suppressor gene family, has not been previously investigated in head and ...
Pterostilbene protects cochlea from ototoxicity in streptozotocin-induced diabetic rats by inhibiting apoptosis

Ozdas, Sibel; Tastekin, Bora; Gurgen, Seren G.; Ozdas, Talih; Pelit, Aykut; Erkan, Sanem O.; Tuhanioglu, Birgul; Gulnar, Birgul; Gorgulu, Orhan (PLOS ONE / PUBLIC LIBRARY SCIENCE, 2020-07)

Diabetes mellitus (DM) causes ototoxicity by inducing oxidative stress, microangiopathy, and apoptosis in the cochlear sensory hair cells. The natural anti-oxidant pterostilbene (PTS) (trans-3,5-dimethoxy-4-hydroxystylbene) ...
Significant association between SCGB1D4 gene polymorphisms and susceptibility to adenoid hypertrophy in a pediatric population

Ozdas, Talih; Ozdas, Sibel; Babademez, Mehmet Ali; Muz, Sami Engin; Atilla, M. Hunturk; Bastimur, Sibel; Izbirak, Afife; Kurt, Kenan; Oz, Isilay (TURKISH JOURNAL OF MEDICAL SCIENCES / TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, 2017)

Background/aim: Adenoid hypertrophy (AH) is chronic enlargement of the adenoid tissue. The pathophysiology of the disease is unclear. We analyzed SCGB1D4 gene polymorphisms in order to determine the effect of the variants ...
The common genetic variants of toll-like receptor and susceptibility to adenoid hypertrophy: a hospital-based cohort study

Babademez, Mehmet Ali; Ozdas, Talih; Ozdas, Sibel (TURKISH JOURNAL OF MEDICAL SCIENCES / TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, 2016)

Background/aim: Adenoid hypertrophy (AH) is one of the most frequent pediatric disorders. The aim of this study was to investigate the effects of TLR2-R753Q, TLR4-T399I, and TLR4-D299G polymorphisms in children with ...

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